The effect of ethanol and temperature on the structural properties of mesoporous silica synthesized by sol-gel method

Document Type: Original Article

Authors

Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Abstract

Mesoporous silica nanoparticles are synthesized in the presence of ethanol as a co-solvent and different temperatures by sol-gel process. The spherical mesoporous silica nanoparticles are obtained at 50°C in presence of 1 ml ethanol. Increasing the reaction temperature with constant amount of ethanol from 30°C to 50°C, decreases the particle size scarcely from 84-115 to 86-94 nm and further increasing of temperature from 50°C to 80°C, increases the particle size to 160 nm with disordered morphology of mesoporous silica nanoparticles. Presence of ethanol leads to formation of high quality, clear and uniform particles with desirable spherical morphology and larger particles up to 170nm in constant temperature. Furthermore, the structural properties of mesoporous silica nanoparticles are improved by increasing ethanol in the synthesis. According to N2 adsorption-desorption, with 5 ml ethanol, the pore size, pore volume and specific surface area are 3.93 nm, 0.40 Cm3 g-1, and 531 m2 g-1, respectively.

Keywords


[1]      Kun-Che Kao, Chung-Yuan Mou. (2013). Pore-expanded mesoporous silica nanoparticles with alkanes/ethanol as pore expanding agent. Microporous and Mesoporous Materials, (169),  7–15.

[2]      L.Slowing, L.Vivero-Scoto, Chia-Wen Wu, S.Y. Lin. (2008). Mesoporous silica nanoparticles as controlled drug delivery and gene transfection carriers. Advanced Drug Delivery Reviews, (60), 1278–1288.

[3]      Sana Kachbouri, Najib Mnasri , Elimame Elaloui , Younes Moussaoui. (2018). Tuning particle morphology of mesoporous silica. Journal of Saudi Chemical Society, (22), 405–415.

[4]      Kota Sreenivasa Rao, Khalil El-Hami, Tsutomu Kodaki, Kazumi Matsushige, Keisuke Makino. (2005). A novel method for synthesis of silica nanoparticles. Journal of Colloid and Interface Science, (289),  125–131.

[5]      G.H. Bogush, C.F. Zukoski, J. (1991).  Colloid Interface Sci. (142), 1.

[6]      Saher Rahmani, Jean-Olivier Durand , Clarence Charnay , Laure Lichon. (2017). Synthesis of mesoporous silica nanoparticles and nanorods: Application to doxorubicin delivery. Solid State Sciences, (68), 25-31.

[7]      Nor Ain Zainal, Syamsul Rizal Abd Shukor, Hajaratul Azwana Ab. Wab, Khairunisak Abdul Razak. (2013). Study on the Effect of Synthesis Parameters of Silica Nanoparticles Entrapped with Rifampicin. The Italian Association of Chemical Engineering, (32), 2245-2250.

[8]      Naiara I. Vazquez, Zoilo Gonzalez, Begona Ferrari, Yolanda Castro. (2017). Synthesis of mesoporous silica nanoparticles bysol–gel as nanocontainer for future drug deliveryapplicationsNaiara. Boletin de la sociedad espanola de ceramica y vidrio, (82), 1-7.

[9]      S.V Lazareva, N.V. Shikina, L.E. Tatarova, Z.R Ismagilov. (2017) Synthesis of high purity silica nanoparticles by sol-gel method. Eurasian Chemico- Technological jurnal, (19), 295-302.

[10]   Qianjun He, Jiamin Zhang, Jianlin Shi, , Ziyan Zhu, Linxia Zhang,Wenbo Bu, Limin Guo, Yu Chen. (2009). The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses. Biomaterials, (31, issue 6), 1085-1092.