%0 Journal Article %T An antibacterial delivery system based on Eucalyptus camaldulensis loaded in starch microspheres %J Journal of Tissues and Materials %I Tissues and Biomaterial Research Group (TBRG)-USERN %Z 2645-3487 %A Sadeghzadeh, Leila %A Rafienia, Mohammad %A Sefidkon, Fatemeh %A Owlia, Parviz %A Negahdari, Babak %A Bonakdar, Shahin %D 2019 %\ 10/29/2019 %V 2 %N 3 %P 18-30 %! An antibacterial delivery system based on Eucalyptus camaldulensis loaded in starch microspheres %K antibacterial %K Drug Delivery %K Eucalyptus oil %K Microspheres %K Starch %R 10.22034/jtm.2019.93448 %X Eucalyptus camaldulensis oil (EO) loaded microspheres were prepared by water-in-oil emulsification cross-linking reaction method using starch as raw material. EO as a natural drug was extracted from Eucalyptus camaldulensis leaves. The effects of mechanical stirrer rate and time of cross-linking on antimicrobial behavior (against Micrococcus luteus and Escherichia coli), morphology and particle size of EO-loaded microspheres were investigated. These microspheres were characterized by FTIR spectroscopy and laser light scattering. Microscopic observations by SEM revealed the spherical and smooth surfaces of the microspheres. Investigations showed that the mean particle size of microspheres decreased from 11.34 to 9.45 µm while the homogenizer speed increased from 8500 to 13500 rpm. Moreover, the microspheres were effective in releasing EO over an extended period of about 100 h in phosphate buffer saline (pH 7.4) and all of the formulations showed antibacterial activity, while this behavior was more noticeable on E. coli. In conclusion, starch microspheres can be used as drug delivery vehicles to sustain the release of antibiotics to prevent infections associated with medical devices. %U