TY - JOUR ID - 93448 TI - An antibacterial delivery system based on Eucalyptus camaldulensis loaded in starch microspheres JO - Journal of Tissues and Materials JA - JTM LA - en SN - 2645-3487 AU - Sadeghzadeh, Leila AU - Rafienia, Mohammad AU - Sefidkon, Fatemeh AU - Owlia, Parviz AU - Negahdari, Babak AU - Bonakdar, Shahin AD - Nanotechnology Researchers Company, Tehran, Iran. AD - Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Research Institute of Forests and Rangelands, Tehran, Iran. AD - Molecular Microbiology Research Center, Shahed University, Tehran, Iran. AD - School of Advanced Technologies in Medicine, Tehran University of Medical Science. Iran. AD - National Cell Bank Department, Pasteur Institute of Iran, Tehran, Iran. Y1 - 2019 PY - 2019 VL - 2 IS - 3 SP - 18 EP - 30 KW - antibacterial KW - Drug Delivery KW - Eucalyptus oil KW - Microspheres KW - Starch DO - 10.22034/jtm.2019.93448 N2 - Eucalyptus camaldulensis oil (EO) loaded microspheres were prepared by water-in-oil emulsification cross-linking reaction method using starch as raw material. EO as a natural drug was extracted from Eucalyptus camaldulensis leaves. The effects of mechanical stirrer rate and time of cross-linking on antimicrobial behavior (against Micrococcus luteus and Escherichia coli), morphology and particle size of EO-loaded microspheres were investigated. These microspheres were characterized by FTIR spectroscopy and laser light scattering. Microscopic observations by SEM revealed the spherical and smooth surfaces of the microspheres. Investigations showed that the mean particle size of microspheres decreased from 11.34 to 9.45 µm while the homogenizer speed increased from 8500 to 13500 rpm. Moreover, the microspheres were effective in releasing EO over an extended period of about 100 h in phosphate buffer saline (pH 7.4) and all of the formulations showed antibacterial activity, while this behavior was more noticeable on E. coli. In conclusion, starch microspheres can be used as drug delivery vehicles to sustain the release of antibiotics to prevent infections associated with medical devices. UR - https://www.jourtm.com/article_93448.html L1 - ER -