Antibacterial hydrogel membrane based on polyvinyl alcohol-hyaluronic acid-zinc oxide nanoparticles for application as wound dressing

Document Type : Original Article


1 Department of Biomedical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran

2 Department of biomaterial engineering, faculity of science and medical technology,science and Research branch, Islamic Azad university

3 Department of tissue engineering, faculity of science and Medical technology , science and research branch, Islamic Azad university

4 Master of Bioelectrics from Islamic Azad University, Birjand Branch

5 -Department of biomedical engineering Islamic Azad University, Mashhad Branch



The skin is the largest organ in the body that protects internal organs from external damage
he does. When the skin is damaged, microorganisms easily attack and cause
Infections occur in humans. Due to the variety of wound dressing products, the possibility of decision making There is a mistake in choosing the right cover for the wounds. Although the most important reasons to use Wound dressings protect the wound from infection and prevent infection, but in reality, the goal The main use is to increase biocompatibility. In this research, an attempt has been made with
Prepare biocompatible wound dressings to enhance the healing process of the accompanying wound, hence the film The polyvinyl alcohol hydrogel is made of hyaluronic acid nanoparticles of zinc oxide. The materials are dispersed with certain percentages together and after the casting process are poured into a plate to dry completely. The obtained films were examined by FTIR test, surface examination using light microscopy and SEM. Examination of the surface morphology has shown that .... . Microstructure was performed using XRD test. The mechanical properties of the films were investigated by tensile test, which increased the percentage of elongation with increasing zinc nanooxide and hyaluronic acid. In vitro studies have shown biocompatibility above 81% for all three scaffolds. Therefore, according to the results of this study, polyvinyl alcohol scaffolds, hyaluronic acid, zinc oxide nanoparticles can be a good option for - - application in tissue engineering (wound dressing).